In a research setting, GHRPs such as ipamorelin are used to isolate naturally occurring GHS in animals. Ipamorelin is used in research settings to stimulate ghrelin, the hunger hormone that an animal’s stomach cells release.
Animal studies frequently create ghrelin infusions in an attempt to increase gastric emptying in animals that are given diabetic or idiopathic gastroparesis for the sake of study. Ipamorelin is often preferred for research settings because it has a significantly longer half-life than ghrelin and has a higher potency than similar peptides when applied in vivo.
Animals also tend to have a much higher tolerance for high applications of ipamorelin compared to similar peptides.
Development and Process
Ipamorelin was specifically designed by scientists as a potent hormone secretagogue to increase the potency and efficacy of pentapeptide exposure in vivo and in vitro.- Profiling of this chemical demonstrates that it antagonists while releasing a ghrp-like receptor.
- Studies in rats comparing the effects of ipamorelin to similar synthetic peptides have described the efficacy and potency of this chemical to that of ghrp-6. However, studies in swine have found that ipamorelin also affects LF, FHS, THS and PRL plasma levels, which ghrp based peptides typically do not.
Comparing Ipamorelin GHRP-6 and GHRP-2
These three chemicals have very similar modes of stimulating some hormones, but have very different effects on the body as a whole.- Each chemical helps a test subject’s body release ghrelin in milligram levels.
- Ghrp-2 tends to increase hormone levels to a higher level than ghrp-6 or ipamorelin.
- In research settings, ghrp-6 has been found to increase hunger at higher levels than other peptides.
- Ghrp-2 raises cortisol, prolactin and aldosterone than ipamorelin.
While imaporelin is generally more highly tolerated in large applications than other experimental peptides, there is still a great deal of research necessary to understand how this chemical interacts with natural substances. Additional factors added to an experimental setting may affect the efficacy in the animal’s body. This should be noted carefully to determine the appropriate application for your test subjects.